Werner Syndrome Helicase

A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.

Also Known As:

RECQ3 Protein; RECQL2 Protein; Werner Syndrome ATP-Dependent Helicase; Werner Syndrome RecQ-Like Helicase; Helicase, Werner Syndrome; Werner Syndrome ATP Dependent Helicase; Werner Syndrome RecQ Like Helicase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Esterases: 1594
      - Deoxyribonucleases: 1284
        Exodeoxyribonucleases: 2
        Werner Syndrome Helicase: 17
      - Exonucleases: 496
        Exodeoxyribonucleases: 2
        Werner Syndrome Helicase: 17
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 8727
        DNA Helicases: 644
        RecQ Helicases: 397
        Werner Syndrome Helicase: 17
  - Isomerases: 467
    - DNA Helicases: 644
      - RecQ Helicases: 397
        Werner Syndrome Helicase: 17
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Poly-ADP-Ribose Binding Proteins
      - Werner Syndrome Helicase: 17
  - Nuclear Proteins: 2740
    - Poly-ADP-Ribose Binding Proteins
      - Werner Syndrome Helicase: 17

Elisabeth Kamper Selected Research

Elisabeth Kamper Research Topics

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